• The explanation for the improvement

  2019-08-11

  

  The explanation for the improvement in survival rates observed for cases diagnosed during the 2000–2004 period compared to the 1991–1994 period for both age groups is not straightforward. Although data from literature suggests that a more frequent PSA testing could imply a decrease of mortality due

• br Conclusions br Authorship contribution

  2019-08-11

  

  Conclusions Authorship contribution Conflicts of interest Acknowledgement The study was funded by the Sanad children’s cancer support association research grant program. Introduction Epithelial carcinomas account for 90% of all ovarian cancers and have been classified into five major

• br Conclusions br Authors contributions br

  2019-08-11

  

  Conclusions Authors’ contributions Ethics approval and consent to participate Availability of data and materials All data generated or analyzed during this study were included in this article and its supplementary information files. And the datasets used and analyzed during the current s

• br Conflict of interest br Author

  2019-08-11

  

  Conflict of interest Author statement Introduction Lung cancer is a major public health problem worldwide since it accounts for 17% and 9% of all cancers in men and women, respectively, and constitutes 19% of all cancer-related deaths [1]. It is estimated that the number of lung cancer deat

• In humans PAKs are widely expressed throughout

  2019-07-30

  

  In humans, PAKs are widely expressed throughout the body with the notable co-expression of all members in the central nervous system (CNS). The biology of these kinases has been extensively probed in complimentary experimental settings and converging results associate all the six PAK members with cy

• Importantly gene silencing of the SLC A the

  2019-07-24

  

  Importantly, gene silencing of the SLC25A13 – the gene encoding for the mitochondrial aspartate-glutamate carrier isoform 2 (AGC2) - does not impair HCC cell line proliferation indicating a specific role of AGC1 in HCC. Unexpectedly, different glucose concentrations do not affect HCC HepG2 cell line

• We conducted the review according to

  2019-07-11

  

  We conducted the review according to PRISMA guidelines and the levels of evidence of included articles were graded according to those of the Oxford Centre for Evidence-Based Medicine [19,20]. The risk of bias was evaluated independently by two authors (JN, MSK) according to predefined criteria (Tabl

• The beneficial impact of global Ces deficiency on

  2019-07-08

  

  The beneficial impact of global Ces3 deficiency on hepatic TAG homeostasis was further tested on the Phosphatidylethanolamine N-methyltransferase (Pemt) knockout and the Ldlr knockout background, which are established mouse models resembling NASH and NAFLD. Notably, Ces3/Pemt as well as Ces3/Ldlr de

• br Lobular architecture The microscopic architecture of

  2019-07-08

  

  Lobular architecture The microscopic architecture of the liver is generally similar in all mammals. The terminal branches of the afferent portal and efferent hepatic veins intertwine, and the sinusoids that bridge the portocentral distance have the most constant spanning distance of any organ in

• The small protein deglycase DJ ubiquitously

  2019-07-06

  

  The small protein deglycase DJ-1, ubiquitously expressed in almost all cells and tissues, is present in the KRN7000 in the cytoplasm, nucleus and to a lesser extension at mitochondria. DJ-1, amongst other things, is implicated in cellular redox homeostasis, mitochondrial protection, inhibition of α

• Both Pericardin and Viking show age

  2019-07-06

  

  Both Pericardin and Viking show age-dependent accumulation in the Drosophila heart (Fig. 2), a phenotype that accompanies severe cardiomyopathy, suggesting that cardiac fibrosis may develop from evolutionarily conserved mechanisms [91,92]. In mouse models of aging, ECM composition around the heart c

• A potent specific thiazoquin az oli one e CD inhibitor

  2019-07-05

  

  A potent specific thiazoquin(az)oli(one)e CD38 inhibitor, 78C, reverses age-related NAD+ decline and improves various aging-related physiological and metabolic parameters [369]. The elevation in NAD+ led to activation of pro-longevity and health-span-related factors such as sirtiuns, AMPK and PPARs,

• FilipinComplex A branch of oxidative stress modulated PTMs s

  2019-07-05

  

  A branch of oxidative stress modulated PTMs stems from lipid and sugar oxidation adducts. Increased lipid peroxidation has been documented to occur in AD brains and within CSF [[109], [110], [111], [112], [113]]. 4-hydroxynonenal (HNE) is one of the most abundant aldehyde by-products of lipid peroxi

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