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br To overcome this limitation it was decided to use
2019-10-08
To overcome this limitation, it Hexa His tag peptide was decided to use the mea-surements obtained from the data collection as a reference. The level of NASA-TLX was calculated using the 80th percentile of data. Based on Pareto principle, the top 20th percentile accounts for approximately 80% of
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br B Quantitative data showing mRNA levels of YAP
2019-10-08
(B) Quantitative data showing mRNA levels of YAP1 and genes of the core components of the IFNR/JAK/STAT antiviral pathway in hCerEC-CTRL Cycloheximide (cells transfected with scrambled non-target siRNA) and hCerEC-siYAP cells (cells transfected with YAP1-specific siRNA). Each bar represents the m
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However at pH the CD spectra of the
2019-10-07
[48]. However, at AZD-5991 2, the CD spectra of the CPF-FA assembly is showing only the positive peak for chiral FA and the absence of peak regarding CPF absorption. So, at pH 2, we can assume the breaking up the CPF-FA assembly as stated earlier and the individual components are resulting. As, CPF
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br Corresponding author br Downregulating survivin
2019-10-07
Corresponding author. 2016). Downregulating survivin or inactivating its function also re-sulted in decreased tumorigenesis and angiogenesis in several in vivo models (Ryan et al., 2009). It is thus clear that survivin overexpression in tumor malignancy is closely associated with unfavorable pr
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br Xin Xin Shang Tian Yang br
2019-10-02
Xin Xin, Shang-Tian Yang William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 151 West Woodruff Ave., Columbus, Ohio 43210, USA • Breast cancer MCF-7 and fibroblast NIH-3T3 Concanamycin A cocultured in 3D microbioreactors. • Cells were engineer
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br Fig Schematic outline of the eight methods used
2019-10-01
3 Fig. 1 Schematic outline of the eight methods used to identify gene expression-based cancer biomarkers. version uses the median as the breakpoint to create the two patient groups, and a related second version of this approach is instead based on a 25th, 75th percentile split [9]. To account
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GW3965 br Corresponding author at Center for Biotechnology a
2019-09-26
Corresponding author at: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, United States of America. this therapy are close to 80%. Despite excellent initial response rates, the 5-year survival for late stage ovar
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br c Department of Epidemiology School
2019-09-25
c Department of Epidemiology, School of Public Health, Nanjing Medical University, China d Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, China e Jiangsu Key Laboratory of Molecular and T
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br Introduction br Platinum based anticancer drugs such as c
2019-09-24
1. Introduction Platinum-based anticancer drugs such as cisplatin, carboplatin and oxaliplatin have been world widely used in the chemotherapy for a variety of solid tumors (Fig. 1) [1]. Application of these classical Pt(II) drugs in clinic has greatly improved the treatment efficacy of many ca
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br could generate plenty of
2019-09-23
could generate plenty of hydroxyl radicals in the weak acidity and the overexpression of H2O2 in solid tumors and cause the apoptosis of cancer cells. Furthermore, [email protected] showed a stronger inhibition ability for tumor in comparison with free CDDP, which could be at-tributed to effective accum
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br Gene expression and comparative genomic hybridization
2019-09-23
2.2. Gene LY3009120 and comparative genomic hybridization (aCGH) microarrays Illumina HumanHT-12 gene expression profiles for the 136 tumours were evaluated as previously described [19]. In brief, data pre-pro-cessing and quantile normalization were applied to the raw signal in-tensities using
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br by LXR RXR are mainly
2019-09-23
by LXR/RXR are mainly involved in cholesterol efflux from Diphenylterazine (DTZ) (re-verse cholesterol transport) through the ATP-binding cassette trans-porters, ABCA1, ABCG5, ABCG8, and ABCG1 [12,48]. It is well known that cholesterol metabolism is dysregulated in different malignant cells. L
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br Furthermore the anti cancer potential of AKBA
2019-09-16
Furthermore, the anti-cancer potential of AKBA was evaluated in an in vivo study. As a result, AKBA treatment significantly reduced A2780/ Taxol tumor volume and slowed tumor growth. AKBA has been shown to decrease the expression of P-gp, as well as LRP, BCRP and MRP both in vivo and in vitro. Abo
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br with equivalent clinical outcomes and suggested capecitab
2019-09-16
with equivalent clinical outcomes and suggested capecitabine as a suitable alternative to 5-FU29. In cases where dose constraints are not achievable, some consider following a European approach utilizing single dose mitomycin C in select patients, which likely has a greater effect on HT than RT
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br Total RNA was isolated from MCF
2019-09-16
Total RNA was isolated from MCF10A-ras Methylpiperidino pyrazole using TRizol® (Invitrogen, Carlsbad, CA, USA) according to the manufacturer's in-structions. To generate complementary DNA (cDNA), 1 μg of total RNA was reverse transcribed by using murine leukemia virus reverse tran-scriptase (Prome