• br Lobular architecture The microscopic architecture of

  2019-07-08

  

  Lobular architecture The microscopic architecture of the liver is generally similar in all mammals. The terminal branches of the afferent portal and efferent hepatic veins intertwine, and the sinusoids that bridge the portocentral distance have the most constant spanning distance of any organ in

• The small protein deglycase DJ ubiquitously

  2019-07-06

  

  The small protein deglycase DJ-1, ubiquitously expressed in almost all cells and tissues, is present in the KRN7000 in the cytoplasm, nucleus and to a lesser extension at mitochondria. DJ-1, amongst other things, is implicated in cellular redox homeostasis, mitochondrial protection, inhibition of α

• Both Pericardin and Viking show age

  2019-07-06

  

  Both Pericardin and Viking show age-dependent accumulation in the Drosophila heart (Fig. 2), a phenotype that accompanies severe cardiomyopathy, suggesting that cardiac fibrosis may develop from evolutionarily conserved mechanisms [91,92]. In mouse models of aging, ECM composition around the heart c

• A potent specific thiazoquin az oli one e CD inhibitor

  2019-07-05

  

  A potent specific thiazoquin(az)oli(one)e CD38 inhibitor, 78C, reverses age-related NAD+ decline and improves various aging-related physiological and metabolic parameters [369]. The elevation in NAD+ led to activation of pro-longevity and health-span-related factors such as sirtiuns, AMPK and PPARs,

• FilipinComplex A branch of oxidative stress modulated PTMs s

  2019-07-05

  

  A branch of oxidative stress modulated PTMs stems from lipid and sugar oxidation adducts. Increased lipid peroxidation has been documented to occur in AD brains and within CSF [[109], [110], [111], [112], [113]]. 4-hydroxynonenal (HNE) is one of the most abundant aldehyde by-products of lipid peroxi

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